Redox-response moieties can also respond to the stimuli in a non-linear fashion. Am. Additionally, a newer generation of liposomes are emerging, focusing on redox sensitive liposomes, magnetic liposomes, enzyme sensitive liposomes and multifunctional smart liposomes [242,243,244,245]. Soc. W. 2015. J. Clin. Nanomedicine and nanoparticle-based delivery systems in plastic and reconstructive surgery. 2023 Mar 27;15(3):393-409. doi: 10.4254/wjh.v15.i3.393. Various nanoformulations including polymeric, liposomes, and lipid-polymer hybrid nanoparticles have already been proposed to improve the biodistribution and targeting capabilities . 4(2), 113121 (2015), B. Kumar et al., In vitro evaluation of silver nanoparticles cytotoxicity on Hepatic cancer (Hep-G2) cell line and their antioxidant activity: green approach for fabrication and application. J. Nanotechnology and Early Cancer Detection and Diagnosis - NCI The nanocomplexes were spherical in shape, which was confirmed by transmission electron microscopy analysis as shown in Fig. The advent of nanotechnology has revolutionized . Disclaimer. Pharm. Keywords: 2015 Jun;93:52-79. doi: 10.1016/j.ejpb.2015.03.018. The findings highlighted the development of a thermo-responsive liposomal drug delivery system for combinational breast cancer treatment [97]. 529(1), 102115 (2017), J.N. Environ. B 3(39), 77247733 (2015), J. Zhang et al., pH-sensitive polymeric nanoparticles for co-delivery of doxorubicin and curcumin to treat cancer via enhanced pro-apoptotic and anti-angiogenic activities. ACS Nano 4(1), 251258 (2010), H. Zhang et al., Daunorubicin-TiO2 nanocomposites as a smart pH-responsive drug delivery system. 11(8), 20712082 (2015), K. Hayashi et al., Magnetically responsive smart nanoparticles for cancer treatment with a combination of magnetic hyperthermia and remote-control drug release. Mater. Biophys. A recent investigation reported that single walled carbon nanotubes were toxic, and induced death of the organs at higher dosages, whereas multi-walled carbon nanotubes in lower dosages could effectively deliver drug for targeted therapy of abnormal cells in breast cancer [205]. 15(5), 17911799 (2018), D. Cui et al., Gastrin-releasing peptide receptor-targeted gadolinium oxide-based multifunctional nanoparticles for dual magnetic resonance/fluorescent molecular imaging of prostate cancer. 8(5), 565580 (2011), L. Sercombe et al., Advances and challenges of liposome assisted drug delivery. Soc. From the above discussion, it is evident that dendrimers are nanoplatforms which can be tuned for therapeutic applications, and show great promise in the treatment of various cancers.
